Lupe was born to parents Luis Ortega and Francisca Lopez on December 23, 1947. She married Domingo S. Villareal on January 3, 1966 in Maricopa County, Arizona , she was a homemaker and had 8 children.
Lupe is survived by her son Paul Villareal; son Domingo Villareal Jr.; son Marcello Villareal and daughter Nativada Corrales; daughter Anna Cardenas; son Rudy Villareal; daughter Carmen Irene Ibarra and her sisters, Doloras Ortega and Natividad Ortega; brother Louis Ortega and Santos Ortega; Thirty Seven grandchildren; and Forty Five great-grandchildren. She is preceded in death by her parents, Luis Ortega and Fransica Lopez; her sister, Mary Rodriguez and her brother Juan Ortega; her daughter Oralia Villareal; grandchildren Cirilo Villareal and Ruben Villareal.
Viewing was held on October 6, 2021 at Greenwood Memory Lawn Mortuary, 2300 W. Van Buren St.,Phoenix 85009 between the hours of 2:00 pm and 6:00 pm. The family is grateful for the condolences.