Karen was born in Burlington, NJ, to parents, William and Margaret Callery. She graduated from Neshaminy High School in 1985, and continued her education, graduating from the College of Philadelphia with a degree in Respiratory Therapy. Karen went on to establish a career, working for Thomas Jefferson University Hospital for over 20 years. She also became a Licensed Pilot and enjoyed life to the fullest.
Karen was preceded in death by her mother Margaret Callery and her sister Dana Callery.
Karen is survived by her father, William Callery Sr., her brother William Callery Jr., and many uncles, aunts, and cousins.