Arnold Caplan

Dr. Arnold I. Caplan (82) of Cleveland, Ohio passed away peacefully on January 10, 2024 with his family lovingly by his side. A distinguished scientist and pioneer, Dr. Caplan left an indelible mark on the field of regenerative medicine during an illustrious career spanning over five decades.

Born January 5, 1942 in Chicago, Dr. Caplan earned his B.S. in Chemistry from the Illinois Institute of Technology and his Ph.D. from The Johns Hopkins University School of Medicine. Joining Case Western Reserve University in 1969, he steadily rose through the academic ranks, becoming a Professor in 1981 and dedicating an impressive 54 years to the institution.

A pivotal moment in his career came with the isolation of human Mesenchymal Stem Cells (MSCs) from adult bone marrow, establishing the conceptual and technical foundation for subsequent global studies. In 1992, he founded Osiris Therapeutics, Inc., commercializing the technology, which later lead to numerous clinical trials worldwide.

Recognized as the father of both basic science and clinical therapeutics of adult Mesenchymal Stem Cells (MSC’s), Dr Caplan's discovered the innate ability of MSC's to modulate the immune system; inhibit both programmed cell death and scar formation; to stimulate blood-vessel formation; and to promote the growth of tissue-specific stem cells. His work has impacted studies and treatment of various human diseases ranging from Multiple Sclerosis and Osteoarthritis to spinal cord injuries to cancer.

Dr. Caplan's warmth and mentorship touched the lives of countless others he trained—shaping the lives of over 150 researchers with his intellect and guidance. His passion extended to sharing his expertise through influential courses, fostering scientific collaboration globally. Honored with many awards including The Marshall R. Urist Award; The Tissue Engineering and Regenerative Medicine International Society Lifetime Achievement Award; and the Case Western Reserve University Faculty Innovator Award. He has over 400 published papers and 20 patents. His contributions shaped the landscape of regenerative medicine.

Beyond the laboratory, Arnold was a devoted husband, father, grandfather, and friend, creating a legacy that extends far beyond scientific achievements. His love for cooking, walks, and deep, meaningful conversations (which often became debates) will be missed by many. He leaves behind a tapestry of cherished memories, instilling values of love, wisdom, and warmth in the hearts of those who knew him.

Arnold I. Caplan is survived by his loving wife of 58 years, Bonnie, his two children Aaron (Tami) Caplan and Rachel (David) Uram and six wonderful grandchildren, Josh, Andrew, and Brian Caplan and Lyla, Sam, and Bella Uram and his brother Herbert (Barbara) Caplan. He lives on through the countless lives touched by his pioneering work and unending love for family and friends.

Services will be held at 2:30p on January 14 at Park Synagogue, 27500 Shaker Blvd, Pepper Pike, Ohio - Simulcast available through Park Synagogue. A private interment will follow.

The family will receive friends at Aaron and Tami Caplan’s residence (25455 Letchworth Road, Beachwood, Ohio) on Jan. 14 from 6:30p to 8:30p, Jan 15 from 2p to 4p and 6:30p to 8:30p, Jan 16 from 2p to 4p and 6:30p to 8:30p, and Jan 17 from 2p to 4p and 6:30p to 8:30p.

Donations in memory of Dr. Caplan, may be made to: The Greater Cleveland Food Bank; Planned Parenthood of Ohio; Rise Up: Northeast Ohio (science education non-profit).

Friends who are unable to attend the service, may view it on Sunday, Janaury14 at 2:30pm by going to https://us02web.zoom.us/j/82780083683?pwd=TmxLbDB5amIrT0FjdmdnN2grcUE4Zz09

Passcode: 665654

Arrangements under the direction of BERKWOITZ-KUMIN-BOOKATZ Memorial Chapel